Everton visit United aiming for a fifth straight away victory – and eighth from 11 league games on the road.
The meeting with Ole Gunnar Solskjaer’s team, perhaps, represents Everton’s toughest away test yet, however.
United have twice won at Goodison Park this season – a league match in November and the following month’s Carabao Cup quarter-final – and are fresh from toppling Southampton 9-0 on Tuesday.
Everton manager Ancelotti insists his ploy for the weekend – when the Italian will continue his rotation policy after both James Rodriguez and Michael Keane were rested for Wednesday’s win at Leeds United – is designed to make life for the hosts as awkward as possible.
“We played two games against Manchester United at home and lost both,” said Ancelotti.
“There is something we have to change, for sure.
“If we follow the same way we played [in the Goodison games], we are going to lose.
“We tried to plan a different strategy and we will see how it works.
“The mental aspect is really important but we have to practically try to do something different – to create more problems than in the past games we played against them.
“United is a fantastic team, with a good mix between experience and talented young players.
“The players know it will be difficult but I hope it will be difficult for United to play against us.
“I am going to rotate other players, this is a normal way I have to manage my squad.
“To avoid injury and to give more motivation to others.”
Ancelotti stopped short of giving away details about his team selection – save for confirming Robin Olsen will retain his place in goal in the absence of Jordan Pickford, who is nursing an abdomen problem.
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Manchester United vs Everton (9:00pm)
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